|Year : 2022 | Volume
| Issue : 2 | Page : 49-54
Understanding the status of the Egyptian coronary lesions: Lesion location and vulnerability
Ibtesam Ibrahim El-Dosouky, Baher Nabil Nashy, Hala Gouda Abomandour
Department of Cardiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
|Date of Submission||27-Mar-2021|
|Date of Decision||15-May-2021|
|Date of Acceptance||08-Jul-2021|
|Date of Web Publication||21-May-2022|
Prof. Ibtesam Ibrahim El-Dosouky
Department of Cardiology, Faculty of Medicine, Zagazig University, Zagazig 44519
Source of Support: None, Conflict of Interest: None
Background: High-probability zones of coronary thrombosis may exist along the coronary tree. We aimed to determine the nature and distribution of significant coronary lesions among our patients. Methods: This study included 529 patients, for whom coronary angiography was done for suspected or proved coronary artery disease (CAD), they were divided into three groups according to the distribution of the coronary lesions: left anterior descending (LAD) group (n = 305) with significant LAD lesion, left circumflex (LCx) group (n = 148) with significant LCx lesion and right coronary artery (RCA) group (n = 181) with significant RCA lesion. Results: One hundred and sixty-nine (31.9%) had nonsignificant lesion, 166 (31.4%) had single-vessel disease, with significantly higher incidence of significant LAD lesion 305 (57.5%) which were proximal 52.4%, LAD lesions were more prone to be the culprit vessel 47.5%, LCx was the least vessel with significant lesion 148 (27.9%), and the least to be prone as a culprit 21.1%. Proximal culprit LAD 63.5% and RCA 55.6% had significantly higher incidence, mid culprit LC× 53.9% had significantly higher incidence. ST-elevation acute coronary syndrome (STE-ACS) was significantly more prevalent in culprit LAD 76.7%. Non-STE-ACS was significantly more prevalent in culprit LC× 56.5% and RCA 55.6%. Conclusion: LAD tends to carry more than one culprit lesion, more to be proximal. Risk factors responsible for instability and sheer stress (uncontrolled diabetes mellitus, uncontrolled hypertension, heavy smoking) were more prevalent between patients with LCx as a culprit followed by RCA in Egyptian; this may throw the light on the need for aggressive control of these risk factors to reduce vulnerability in these patients.
Keywords: Acute coronary syndrome, significant coronary lesion, vulnerable plaque
|How to cite this article:|
El-Dosouky II, Nashy BN, Abomandour HG. Understanding the status of the Egyptian coronary lesions: Lesion location and vulnerability. J Indian coll cardiol 2022;12:49-54
|How to cite this URL:|
El-Dosouky II, Nashy BN, Abomandour HG. Understanding the status of the Egyptian coronary lesions: Lesion location and vulnerability. J Indian coll cardiol [serial online] 2022 [cited 2022 Oct 2];12:49-54. Available from: https://www.joicc.org/text.asp?2022/12/2/49/345622
| Introduction|| |
Atherosclerotic coronary artery disease (CAD) has an early onset, a long latent period with heterogeneity in its phenotypic and clinical expression. It still represents the main cause of death among all cardiovascular disease.
There is a constant interaction between blood flow and arterial geometry. While the blood circulates through the vasculature with every cardiac cycle, the vessel geometry alters the hemodynamic characteristics; consequently changes in blood flow affect the morphology and function of arteries, resulting in the production of a complex hemodynamic pattern.,
High-probability zones of coronary thrombosis may exist along the coronary tree., As the coronary arteries are tethered to the surface of the beating heart, they undergo cyclic longitudinal deformations by axial bending (flexion) and stretching, cyclic flexion may fatigue and weaken the plaque on long-term, while a sudden accentuated longitudinal flexion may trigger plaque disruption.,
Atheromatous plaque rupture with superimposed thrombosis is the main step in the pathogenesis of acute coronary syndromes (ACS). Which coronary vessel is the culprit and where is the vulnerability within the different clinical presentations of CAD-is unclear? Various studies have found inconsistent variabilities in the distribution of culprit lesions among coronary arteries in patients presenting with ACS. The proximal and mid portions of the coronary arteries have been identified as the most frequent sites of plaque rupture with a higher incidence in the proximal portion of the left anterior descending artery (LAD), and an underrepresentation of the left circumflex coronary artery (LCx) in STEMI.,
Aim of the study
We tried to determine the prevalence and factors associated with proximal, mid, and distally located significant lesions in the LAD, LCx, and right coronary arteries (RCAs) between our patients.
| Methods|| |
This retrospective cross-sectional study included 529 patients, for whom coronary angiography was done for suspected or proved CAD (either ACS, chronic stable angina). Patients with heart failure, severe renal impairment with estimated glomerular filtration rate eGFR<30 ml/min/1.73m2, advanced degree of valve lesion, previous bypass graft or percutaneous coronary intervention with stenting, atrial fibrillations, malignancy or chronic inflammatory disease were excluded from the study.
Approval was obtained for performing the study from the Ethical Committee of the Faculty of Medicine, Zagazig University, Egypt.
As the rule before all coronary angiography, after giving written informed consent, all patients were subjected to the following:
- Full history taking specifically the history of typical ischemic chest pain, demographic data and risk factors of CAD
- Thorough clinical examination, body mass index calculation was of special concern
- Electrocardiographic (ECG) examination: Standard 12-lead surface ECG was done for every patient. It was analyzed by 2 different physicians to diagnose ST-elevation ACS (STE-ACS) and non-STE-ACS (NSTE-ACS), according to the guidelines
As our concern was the type of presentation and coronary lesion distribution, left ventricular ejection fraction, and wall-motion score index were not included in our study.
- Laboratory investigations: Mainly for high sensitivity troponin
- Coronary angiography: Coronary angiography was performed using Judkin's method, following the puncture of the femoral artery or via a radial artery approach. The severity of coronary atherosclerotic lesions was evaluated from at least 3 projections in all the patients for the visual classification of the coronary artery map in accordance with the guidelines of the American College of Cardiology/American Heart Association. In ACS, we relied upon ECG or echocardiographic identification of the myocardial area at risk to conclude that the “culprit” artery was the artery with at least one lesion that needed acute intervention.
In other patients, the culprit lesions were identified and treated by the operator on-site depending on the extent and severity of narrowing as well as the findings of stress tests (ECG, echocardiographic, or nuclear) or fractional flow reserve measured. All these data were recorded in the database of the cath. Lab from which we collected.
Significant stenosis was defined as diameter stenosis of 70% or greater.
Coronary artery territories and its segments
- Left main: From the ostium of the LCA through bifurcation into LAD and LCx branches
- LAD proximal: Proximal to and including first major septal branch
- LAD mid: LAD immediately distal to the origin of first septal branch and extending to the point where LAD forms an angle (RAO view). If this angle is not identifiable this segment ends at one-half the distance from the first septal to the apex of the heart
- LAD distal: It is the segment distal to the described mid-segment
- LCx artery proximal: Mainstem of circumflex from its origin from the left main and including origin of the first obtuse marginal branch
- Mid LCx: It is the mid part of the LCx and of the proximal 1–2 cm of obtuse marginal branches
- Distal LCx: The stem of the circumflex distal to the origin of the most distal obtuse marginal branch, and running along the posterior atrioventricular groove
- RCA proximal: From the ostium to one-half the distances to the acute margin of the heart
- RCA mid: From the end of the first segment to the acute margin of the heart
- RCA distal: From the acute margin of the heart to the origin of the posterior descending artery
- We divided our patients into three groups according to the CAD and culprit lesion:
º LAD group: 305 patients with significant LAD lesion
º LCx group: 148 patients with significant LCx lesion
º RCA group: 181 patients with significant RCA lesion.
All data were analyzed using SPSS software Statistical Package for the Social Science version 19 (SPSS, Inc. Chicago, IL, USA). Results were presented as mean value ± standard deviation for continuous variables and as frequency (%) for categorical variables. Data were tested for normality using the KolmogorovSmirnov test. Means were compared using ANOVA, Student's t-test, or MannWhitney test according to the number of groups in comparison. Categorical data were compared using Chi-squared test. P value was set at <0.05 for significant results and <0.001 for highly significant results.
| Results|| |
166 (31.4%) of our patients had single vessel disease, 111 (21%) had 2 vessel disease, 83 (15.7%) with 3 vessel disease and 169 (31.9%) had nonsignificant lesion.
Demographic data of the patients are in [Table 1], with significantly higher incidence of significant LAD lesion 305 (57.5%), followed by RAC 181 (34.2%), while LCx showed the least incidence 148 (27.9%).
LCx and RCA groups had older age (57.1 ± 9.9 and 57.7 ± 9.9) compared to those in the LAD group (55.7 ± 10.6), with no significant difference; P > 0.05.
Hypertension was significantly more prevalent in LCx 101 (68.2%) and RCA 117 (64.6%) groups compared to LAD group 156 (54.1%) (P < 0.05).
Significantly higher incidence of smoking in LCx 84 (56.8%) group compared to LAD 136 (44.4%) group (P < 0.05).
Diabetes mellitus (DM) was significantly more prevalent in LCx group 75 (50.7%) compared to LAD group 128 (42%) (P < 0.05).
[Table 2] shows the angiographic characters of the groups:
Between single-vessel disease, LAD was significantly more prevalent 41%, followed by RCA 27.1% (P < 0.05) and LCx 13.3% (P < 0.001).
52.4% of LAD lesions were proximal compared to 42.8% in LCx and 36.7% in RCA (P < 0.05 to all).
Incidence of the mid lesion was significantly more in RCA 50% compared to LCx 42.9% (P < 0.05).
Distal lesion was significantly more prevalent in RCA 20.4% compared to LCx 11.9% (P < 0.05) and LAD 9.5% (P < 0.001).
Incidence of ectataic lesion was significantly higher in RCA 6.1% and LCx 7% compared to LAD 3.2% (P < 0.05).
The incidence of multiple lesions was significantly more prevalent in LAD vessel 22.1% followed by LCx 7.2% and RCA2% (P < 0.001).
[Table 3] and [Table 4] show the demographic and angiographic characters of the culprit's vessels:
Significantly higher incidence of culprit LAD lesion 27.6% compared to RCA 7% and LCx 5.9% between all patients (P < 0.001 to all).
LAD with significant lesion was significantly more prone to be the culprit vessel 47.5%, compared to LCx 21.1% and RCA 20.4% (P < 0.001).
Patients with culprit LAD and those with culprit RCA showed significantly more male predominance (88.4% and 88.6%, respectively) compared to those with LCx 77.4% culprit (P < 0.05).
Hypercholesterolemia was significantly more prevalent between those with culprit RCA 76.4% compared to those with LCx 61.3% and LAD 64.4% (P < 0.05).
Incidence of hypertension was significantly more in culprit LCx 80.6% followed by RCA 62.2% (P < 0.05) compared to LAD 41.1% (P < 0.001).
Incidence of smoking was significantly more in culprit LCx 71% and RCA 70.3% compared to LAD 42.5% (P < 0.001).
Incidence of DM was significantly more in culprit LCx 58.1% compared to RCA 43.2% (P < 0.05) and LAD 35.6% (P < 0.001), and showed significant differences in culprit RCA compared to LAD (P < 0.05).
Family history of CAD was significantly more in culprit LCx 54.8% compared to RCA 43.2% (P < 0.05) and LAD 31.5% (P < 0.001), and showed significant differences in culprit RCA compared to LAD (P < 0.05).
Proximal culprit LAD 63.5% and RCA 55.6% had significantly higher incidence compared to LCx 38.5% (P < 0.05).
Mid culprit LCx 53.9% had significantly higher incidence compared to RCA 38.9% and LAD 36.2% (P < 0.05).
Distal culprit LCx 7.7% had significantly higher incidence compared to RCA 3% (P < 0.05).
STE-ACS was significantly more prevalent in culprit LAD 76.7% compared to RCA 44.4% and LCx 43.5% (P < 0.001).
NSTE-ACS was significantly more prevalent in culprit LCx 56.5% and RCA 55.6% compared to LAD 23.3% (P < 0.001).
Troponin level was significantly higher in those with culprit LAD 6.1 ± 7.2 versus 0.17 ± 0.2 in RCA and 0.01 in LCx (P < 0.001).
| Discussion|| |
Atherosclerosis is a complex, involving endothelial cells, smooth muscle cells, and arterial extracellular matrix macromolecules, which undergo a phenotypic switch from their normal physiological function to a pathological one under the effect of local flow hemodynamics and inflammatory mechanisms.
The identification and control of coronary risk factors, such as diabetes, smoking, arterial hypertension, and hyperlipidemia, is the cornerstone of preventative strategies.
Local and systemic factors coexist to initiate atherosclerosis and allow its progress; atherosclerotic lesions tend to form at certain arterial segments despite the systemic effect of risk factors on all arteries.
Several studies have now validated the low shear stress hypothesis of atherosclerosis., Low/oscillatory endothelial shear stress is an important key factor in atherosclerosis initiation and progression as it is implicated in the critical switch from normal physiological to pathological one. Laminar flow and unidirectional high shear stress are atheroprotective.
These observations highlight the importance of local hemodynamic conditions in susceptible individuals with CAD risk factors.
There was no difference regarding age and gender among all groups with significant coronary lesion. There was male predominance in all groups regarding the presence of culprit lesions, in agreement with Ozaki et al., with fewer females in LAD and RCA compared to LCx while Halim et al. found fewer women among patients with a culprit LCx compared with those with a culprit LAD or RCA as he studied those with NSTE-ACS only.
LAD lesion was more prevalent, it tends to carry multiple lesions mainly proximal that were more prone to be sites of culprit lesions and to be presented as STE-ACS than the other vessels, in agreement with Wang, et al and Katritsis, et al.
RCA significant lesions were more frequent in the midsegments followed by the proximal one, but the proximal segment was more prone to be the site of the culprit lesion.
LCx was the least vessel to carry significant lesion which were equally distributed between proximal and mid segments, the midsegments were more prone to have culprit lesions this was in agreement with Katritsis et al. while Wang et al. detected that LCx thrombosis was more frequent in the proximal segment. Culprit LCx presented in most cases as NSTE-ACS, these results were in correlation with Antoni et al., From et al., and Ghanim et al. this could be due to lesser LCx longitudinal strain that makes the plaque less prone to rupture, with lesser transmural ischemia.
The LAD, most of the RCA, and the mid to distal LCx and its branches pass along the LV longitudinal axis. The proximal-to-mid LCx, pass in the atrioventricular groove along the circumferential axis of the base of the heart. This anatomy can explain why there is higher shear stress on the proximal LAD and RCA with the predominance of the culprit lesions in their proximal segments and a lower incidence of the proximal LCx as a site of culprit lesion due to higher RCA and LAD systolic shortening.
In our study, troponin level was significantly higher in those with culprit LAD than RCA and was the least in LCx, this was in disagreement with Halim et al. study and Antoni et al., who demonstrated that patients with a culprit lesion in the LAD and LCx had significantly higher-peak cardiac enzymes compared with patients with culprit lesions in the RCA this discrepancy may be due to their selection of patients with NSTE-ACS only. In our study, LCx as a culprit had a higher incidence of NSTE-ACS which incorporated those with unstable angina who had no enzyme elevation. LAD as an artery (more prone to carry culprit lesion) supplies a larger area of the heart, with a higher incidence of STE-ACS with a higher enzyme release.
Our analysis depended on the two-dimensional coronary angiograms, that lakes good assessment of spatial anatomic relationships and not study the characters of the vulnerable plaques. We did not study the TIMI flow or the SYNTAX score.
| Conclusion|| |
LAD tends to carry more than one culprit lesion more to be proximal. Risk factors responsible for instability and sheer stress (uncontrolled DM, uncontrolled hypertension, heavy smoking) were more prevalent between patients with LCx as a culprit followed by RCA in Egyptian; this may draw the attention for aggressive control of these risk factors to reduce vulnerability in these patients.
Further studies of human coronary anatomy using intravascular ultrasound, as well as in-depth analysis of coronary hemodynamics with the study of the coronary flow reserve, TIMI, and myocardial blush, are necessary for characterization and identification of coronary lesions.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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[Table 1], [Table 2], [Table 3], [Table 4]